New York :
Pharmaceuticals Pfizer and Moderna have pioneered the United States in obtaining FDA emergency use authorization for their COVID-19 vaccines, but also by developing drugs that use a new technology known as “messenger RNA” (mRNA).
Given such innovative technology and the imminent distribution of new vaccines in this country and in the world, it is normal to ask: And how does it feel to get the coronavirus vaccine from Pfizer or Moderna? Some volunteers who have participated in phase 3 clinical trials in the US have recounted their experience.
How do they work?
The EEEU National Cancer Institute defines messenger RNA as a type of RNA found in cells that contains “the genetic information needed to make proteins and carries this information from the DNA in the nucleus of the cell to the cytoplasm where proteins are made ”.
Unlike traditional vaccines, in which a dose of live or attenuated virus is injected into the body, These vaccines contain the genetic instruction for the body to make a protein on its own, the peak protein that contains SARS-CoV2. In turn, this instruction activates the immune system that begins to produce antibodies against the new, hitherto unknown protein.
A second dose of the drug is required to increase the response of the immune system and achieve the effectiveness close to 95 percent declared by both companies. In this way, when the body comes into contact with the real virus, it is ready to fight it. MRNA technology has been studied for decades to fight other infections and even certain types of cancer.
What it feels like
A 24-year-old volunteer who received a dose of the experimental vaccine After signing up for the trial through the National Institutes of Health (NIH) website, he told CNN what his experience was like.
Yasir Batalvi notes that, after signing a 22 page long consent formHe was a bit nervous before receiving the first injection, but felt he had to participate “as a civic duty.”
Then he relates that the first injection felt like any other vaccine. At night, the pain in his arm prevented him from moving it much over his shoulder, but it was “definitely manageable.” However, on receiving the second dose the symptoms were a bit clearer. “That night was difficult. I mean, I developed a low fever and fatigue and chills, ”the young man told the publication. However, Batalvi ensures that people can feel safe taking it. “I took the vaccine, it was good. I think we can overcome it, “he added.
Batalvi’s symptoms are a normal response to a vaccine. The doctor Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, told Mark Zuckerberg these mild side effects disappear in 24 hours, 48 maximum. “What the body is telling you with that response is that it is responding well to the injection,” he said..
Fauci clarified that some people may not feel anything while others experience arm pain, a flu-like sensation and, a minority of people, fever. “Frankly, compared to 95 percent protection against an infection that can be deadly or significantly debilitating, I think it’s a fair balance.“, He pointed.